Journal article

Corpus Callosum Size and Shape in Individuals with Bipolar Disorder and Their Relatives

M Walterfang, A Wood, S Barton, D Velakoulis, J Chen, C Pantelis, D Reutens, M Kempton, M Haldane, S Frangou

European Psychiatry | Cambridge University Press (CUP) | Published : 2009

Abstract

Objective:To examine genetic influences the anatomy of the Corpus Callosum (CC) in Bipolar Disorder (BD) by examining first-degree relatives in addition to BD patients.Methods:We compared CCl size and shape in 180 individuals: 70 with BD, 45 of their unaffected first-degree relatives, and 75 healthy controls. The CC was extracted from a mid-sagittal slice from T1-weighted magnetic resonance images; its total area, length and curvature were compared across groups. A non-parametric permutation method was used to examine for alterations in width of the callosum along 39 points.Results:Validating our previous findings, a significant global reduction in CC thickness was seen in BD patients, with ..

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