Journal article

Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance

Garron T Dodd, Seung Jae Kim, Mathieu Mequinion, Chrysovalantou E Xirouchaki, Jens C Bruening, Zane B Andrews, Tony Tiganis

SCIENCE ADVANCES | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2021

Abstract

The importance of hypothalamic insulin signaling on feeding and glucose metabolism remains unclear. We report that insulin acts on AgRP neurons to acutely decrease meal size and thereby limit postprandial glucose and insulin excursions. The promotion of insulin signaling in AgRP neurons decreased meal size without altering total caloric intake, whereas the genetic ablation of the insulin receptor had the opposite effect. The promotion of insulin signaling also decreased the intake of sucrose-sweetened water or high-fat food over standard chow, without influencing food-seeking and hedonic behaviors. The ability of heightened insulin signaling to override the hedonistic consumption of highly p..

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Grants

Funding Acknowledgements

This work was supported by the National Health and Medical Research Council (NHMRC) of Australia (to T.T. and Z.B.A.); T.T. and Z.B.A. are NHMRC Research Fellows.