Journal article

Postprandial rise of essential amino acids is impaired during critical illness and unrelated to small intestinal function.

Rob JJ van Gassel, Marcel C G van de Poll, Frank G Schaap, Mark Plummer, Adam Deane, Steven WM Olde Damink

Journal of Parenteral and Enteral Nutrition | Published : 2021


BACKGROUND: Postprandial rise of plasma essential amino acids (EAA) determines the anabolic effect of dietary protein. Disturbed gastro-intestinal function could impair the anabolic effect of enteral nutrition in critically ill patients. Our aim was to investigate the EAA response following an enteral nutrition bolus in critically ill patients and its relation to small intestinal function. METHODS: Twenty-one mechanically ventilated patients and nine healthy controls received a bolus containing 100 mL of a formula feed (Ensure) and 2 g of 3-O-Methyl-d-Glucose (3OMG) via post-pyloric feeding tube. Fasting and post-prandial plasma concentrations of EAA, 3-OMG, total bile salts and the gut-rele..

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