Reducing intracranial pressure by reducing central venous pressure: assessment of potential countermeasures to spaceflight-associated neuro-ocular syndrome.
Alexander B Hansen, Justin S Lawley, Caroline A Rickards, Erin J Howden, Satyam Sarma, William K Cornwell, Sachin B Amin, Hendrik Mugele, Kyohei Marume, Carmen Possnig, Louis A Whitworth, Michael A Williams, Benjamin D Levine
Journal of Applied Physiology | Published : 2021
Spaceflight-associated neuro-ocular syndrome (SANS) involves unilateral or bilateral optic disc edema, widening of the optic nerve sheath, and posterior globe flattening. Owing to posterior globe flattening, it is hypothesized that microgravity causes a disproportionate change in intracranial pressure (ICP) relative to intraocular pressure. Countermeasures capable of reducing ICP include thigh cuffs and breathing against inspiratory resistance. Owing to the coupling of central venous pressure (CVP) and intracranial pressure, we hypothesized that both ICP and CVP will be reduced during both countermeasures. In four male participants (32 ± 13 yr) who were previously implanted with Ommaya reser..View full abstract