Control of cystic echinococcosis in the Middle Atlas, Morocco: Field evaluation of the EG95 vaccine in sheep and cesticide treatment in dogs
Fatimaezzahra Amarir, Abdelkbir Rhalem, Abderrahim Sadak, Marianne Raes, Mohamed Oukessou, Aouatif Saadi, Mohammed Bouslikhane, Charles G Gauci, Marshall W Lightowlers, Nathalie Kirschvink, Tanguy Marcotty
PLOS Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2021
BACKGROUND: Cystic echinococcosis (CE) is an important cause of human morbidity and mortality worldwide, particularly in Morocco and other North African countries. METHODOLOGY/PRINCIPAL FINDINGS: We investigated the potential of three strategies to reduce Echinococcus granulosus transmission: (1) 4-monthly treatment of dogs with praziquantel, (2) vaccination of sheep with the EG95 vaccine and (3) a combination of both measures. These measures were implemented during four consecutive years in different areas of the Middle Atlas Mountains in Morocco. The outcome of the interventions was assessed through hydatid cyst (viable and non-viable) counts in liver and lungs using necropsy or in vivo ul..View full abstract
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Awarded by Australian National Health and Medical Research Council
This study has received funding for the various works carried out in the field, from the Academy of Research and Higher Education (ARES) of Belgium, Namur Research Institut (NARILIS), University of Namur, Belgium, Hassan II Agronomy and Veterinary Institute (IAV), Rabat, Morocco and Australian National Health and Medical Research Council Grant GTN1105448 (MWL). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.