3-YEAR RESULTS OF THE PHASE 2 RANDOMIZED TRIAL FOR TALIMOGENE LAHERPAREPVEC (T-VEC) NEOADJUVANT TREATMENT PLUS SURGERY VS SURGERY IN PATIENTS WITH RESECTABLE STAGE IIIB-IVM1A MELANOMA

Abstract

Neoadjuvant immunotherapies and targeted therapies for advanced melanoma are an active area of investigation. This is the first clinical trial of an approved oncolytic viral immunotherapy as a neoadjuvant treatment in advanced melanoma and the largest randomized controlled neoadjuvant trial including all types of resectable regional metastases to date. Previously published 2-year primary analysis results reported improved recurrence-free survival (RFS, HR 0.66, P=0.038) and overall survival (OS, HR 0.49, P=0.050) for neoadjuvant T-VEC plus surgery vs immediate surgery in resectable stage IIIB-IVM1a melanoma patients.1 Here, we report the 3-year interim analysis results. Patients with resecta..