Journal article

What level of neutralising antibody protects from COVID-19?

David Khoury, Deborah Cromer, Arnold Reynaldi, Timothy Schlub, Adam Wheatley, Jennifer Juno, Kanta Subbarao, Stephen Kent, James Triccas, Miles Davenport

Cold Spring Harbor Laboratory | Published : 2021

Abstract

Both previous infection and vaccination have been shown to provide potent protection from COVID-19. However, there are concerns that waning immunity and viral variation may lead to a loss of protection over time. Predictive models of immune protection are urgently needed to identify immune correlates of protection to assist in the future deployment of vaccines. To address this, we modelled the relationship between in vitro neutralisation levels and observed protection from SARS-CoV-2 infection using data from seven current vaccines as well as convalescent cohorts. Here we show that neutralisation level is highly predictive of immune protection. The 50% protective neutralisation level was est..

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