Journal article

X-ray-Based Techniques to Study the Nano-Bio Interface

Carlos Sanchez-Cano, Ramon A Alvarez-Puebla, John M Abendroth, Tobias Beck, Robert Blick, Yuan Cao, Frank Caruso, Indranath Chakraborty, Henry N Chapman, Chunying Chen, Bruce E Cohen, Andre LC Conceição, David P Cormode, Daxiang Cui, Kenneth A Dawson, Gerald Falkenberg, Chunhai Fan, Neus Feliu, Mingyuan Gao, Elisabetta Gargioni Show all

ACS Nano | American Chemical Society | Published : 2021

Abstract

X-ray-based analytics are routinely applied in many fields, including physics, chemistry, materials science, and engineering. The full potential of such techniques in the life sciences and medicine, however, has not yet been fully exploited. We highlight current and upcoming advances in this direction. We describe different X-ray-based methodologies (including those performed at synchrotron light sources and X-ray free-electron lasers) and their potentials for application to investigate the nano-bio interface. The discussion is predominantly guided by asking how such methods could better help to understand and to improve nanoparticle-based drug delivery, though the concepts also apply to nan..

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Grants

Awarded by Cluster of Excellence 'Advanced Imaging of Matter' of the Deutsche Forschungsgemeinschaft (DFG) - EXC 2056


Awarded by Maria de Maeztu Units of Excellence Programme Ministry of Science, Innovation and Universities


Awarded by Gipuzkoa Foru Aldundia (Gipuzkoa Fellows program)


Awarded by Ministerio de Economia y Competitividad


Awarded by Generalitat de Cataluna


Awarded by Universitat Rovira i Virgili


Awarded by National Health and Medical Research Council Senior Principal Research Fellowship


Awarded by Australian Research Council Centre of Excellence in Convergent BioNano Science and Technology


Awarded by National Key R&D Program of China


Awarded by Key Research Program of Frontier Sciences


Awarded by European Research Council (ERC AdG 4DbioSERS)


Awarded by BMBF


Awarded by U.S. National Science Foundation


Awarded by BioXFEL STC


Funding Acknowledgements

Parts of this work were supported by the Cluster of Excellence 'Advanced Imaging of Matter' of the Deutsche Forschungsgemeinschaft (DFG) - EXC 2056 -project ID 390715994. Part of this work was performed under the Maria de Maeztu Units of Excellence Programme - grant no. MDM2017-0720 Ministry of Science, Innovation and Universities. C.S.C. thanks Gipuzkoa Foru Aldundia (Gipuzkoa Fellows program; grant no. 2019-FELL-000018-01/62/2019) for financial support. R.A.A.P. acknowledges the Ministerio de Economia y Competitividad (CTQ2017-88648R), the Generalitat de Cataluna (2017SGR883), and the Universitat Rovira i Virgili (2019PFR-URV-B2-02) for financial support. F.C. acknowledges the award of a National Health and Medical Research Council Senior Principal Research Fellowship (GNT1135806) and support from the Australian Research Council Centre of Excellence in Convergent BioNano Science and Technology (project no. CE140100036). F.G., C.K., Y.L., and O.S. acknowledge DESY (Hamburg, Germany), a member of the Helmholtz Association HGF, for the provision of experimental facilities. Parts of this research were carried out at PETRA III, and we would like to thank the beamline team for assistance in using P21.1. C.F. and Y.Z. thank the National Key R&D Program of China (2016YFA0400900) for financial support. Y.Z. also acknowledges the Key Research Program of Frontier Sciences (QYZDJ-SSW-SLH031) and the LU Jiaxi International Team of the Chinese Academy of Sciences. Y.H., Y.K., Y.L., Z.L., B.Q., X.S., and H.Y. acknowledge the Chinese Scholarship Council for funding. N.K. thanks the Alexander von Humboldt Foundation for a Visiting Professorship. L.M.L.-M. acknowledges funding by the European Research Council (ERC AdG 4DbioSERS, no. 787510). A.K.S. and M.K.S. thank the Department of Science and Technology, India, for support. K.R. acknowledges support by BMBF grant nos. 02NUK032 and 02NUK035B. D.M.S. and P.S.W. thank the U.S. National Science Foundation, grant no. CHE2004238, for support. Part of the phytochrome work is supported by BioXFEL STC grant no. NSF-1231306.