Hemagglutinin Functionalized Liposomal Vaccines Enhance Germinal Center and Follicular Helper T Cell Immunity
Mai N Vu, Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Thomas P Davis, Nghia P Truong, Adam K Wheatley, Stephen J Kent
ADVANCED HEALTHCARE MATERIALS | WILEY | Published : 2021
Despite remarkable successes of immunization in protecting public health, safe and effective vaccines against a number of life-threatening pathogens such as HIV, ebola, influenza, and SARS-CoV-2 remain urgently needed. Subunit vaccines can avoid potential toxicity associated with traditional whole virion-inactivated and live-attenuated vaccines; however, the immunogenicity of subunit vaccines is often poor. A facile method is here reported to produce lipid nanoparticle subunit vaccines that exhibit high immunogenicity and elicit protection against influenza virus. Influenza hemagglutinin (HA) immunogens are functionalized on the surface of liposomes via stable metal chelation chemistry, usin..View full abstract
Awarded by Australian Research Council (ARC)
Awarded by DECRA Fellowship from the ARC
Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology
The authors would like to thank Dr. Andrew Leis (University of Melbourne) for assistance with Cryo-TEM and Mr. Nam Dao (Monash University) for his help on liposome preparation. T.P.D., N.P.T., and S.J.K. acknowledge the receipt of a Discovery Project grant (DP200100231) from the Australian Research Council (ARC). N.P.T. is grateful for the award of a DECRA Fellowship from the ARC (DE180100076). This work was carried out within the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036). M.N.V. acknowledges the financial support from Monash Graduate Scholarship (MGS) and Monash International Postgraduate Research Scholarship (MIPRS).