Gut microbiome, prebiotics, intestinal permeability and diabetes complications
Matthew Snelson, Cassandra de Pasquale, Elif I Ekinci, Melinda T Coughlan
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | ELSEVIER SCI LTD | Published : 2021
Diabetes is a metabolic condition. The composition of the gut microbiota is altered in diabetes with reduced levels of short chain fatty acids (SCFA) producers, notably butyrate. Butyrate is associated with a number of beneficial effects including promoting the integrity of the gastrointestinal barrier. Diabetes may lead to an increase in the permeability of the gut barrier, which is thought to contribute to systemic inflammation and worsen the microvascular complications of diabetes. Prebiotics, non-digestible carbohydrates, are fermented by the colonic microbiota leading to the production of a range of metabolites including SCFAs. Thus, prebiotics represent a dietary approach to increase l..View full abstract
EIE is supported by the Sir Edward Weary Dunlop Foundation. EIE's research is supported by funding from the National Health and Medical Research Council (NHMRC) of Australia, Medical Research Future Fund. EIE's institute receives funding from Novo Nordisk, Gilead, Bayer, Eli Lilly, Sanofi, Boehringer for unrelated research.