Journal article

A comparison of alternative mRNA splicing in the CD4 and CD8 T cell lineages

Xin Liu, Matthew Andrews, Jarrod P Skinner, Timothy M Johanson, Mark MW Chong

MOLECULAR IMMUNOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2021

Abstract

T cells can be subdivided into a number of different subsets that are defined by their distinct functions. While the specialization of different T cell subsets is partly achieved by the expression of specific genes, the overall transcriptional profiles of all T cells appear very similar. Alternative mRNA splicing is a mechanism that facilitates greater transcript/protein diversity from a limited number of genes, which may contribute to the functional specialization of distinct T cell subsets. In this study we employ a combination of short-read and long-read sequencing technologies to compare alternative mRNA splicing between the CD4 and CD8 T cell lineages. While long-read technology was eff..

View full abstract

University of Melbourne Researchers

Grants

Awarded by Australian National Health and Medical Research Council, Australia


Funding Acknowledgements

This work was funded by grants from the Australian National Health and Medical Research Council, Australia (GNT1122384 and GNT1122395). M.M.W.C. is a Senior Research Fellow of the Australian National Health and Medical Research Council. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian National Health and Medical Research Council Research Institute Infrastructure Support Schemes.