For Whom the Bell Tolls: The Structure of the Dead Kinase, IRAK3

Christopher R Horne; James M Murphy

Journal article

For Whom the Bell Tolls: The Structure of the Dead Kinase, IRAK3

Christopher R Horne, James M Murphy

STRUCTURE | CELL PRESS | Published : 2021

DOI: 10.1016/j.str.2021.01.011

Abstract

In this issue of Structure, Lange et al. (2020) report the structure of the pseudokinase domain of IRAK3, a negative regulator of Myddosome inflammatory signaling. The IRAK3 pseudokinase domain forms a head-to-head dimer, suggesting a new mode of kinase/pseudokinase allostery by which IRAK3 could attenuate the activity of IRAK4 in cells.

University of Melbourne Researchers

James Murphy Author Medical Biology (w.e.h.i.)

Chris Horne Author Medical Biology (w.e.h.i.)

Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Awarded by NHMRC IRIISS

Funding Acknowledgements

J.M.M. thanks the National Health and Medical Research Council of Australia (NHMRC) for fellowship support (1172929). The authors gratefully acknowledge infrastructure support from NHMRC IRIISS (9000653) and the Victorian State Government Operational Infrastructure Support Scheme.