For Whom the Bell Tolls: The Structure of the Dead Kinase, IRAK3
Christopher R Horne, James M Murphy
STRUCTURE | CELL PRESS | Published : 2021
In this issue of Structure, Lange et al. (2020) report the structure of the pseudokinase domain of IRAK3, a negative regulator of Myddosome inflammatory signaling. The IRAK3 pseudokinase domain forms a head-to-head dimer, suggesting a new mode of kinase/pseudokinase allostery by which IRAK3 could attenuate the activity of IRAK4 in cells.
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by NHMRC IRIISS
J.M.M. thanks the National Health and Medical Research Council of Australia (NHMRC) for fellowship support (1172929). The authors gratefully acknowledge infrastructure support from NHMRC IRIISS (9000653) and the Victorian State Government Operational Infrastructure Support Scheme.