Annexin A1 Is Required for Efficient Tumor Initiation and Cancer Stem Cell Maintenance in a Model of Human Breast Cancer
Cameron N Johnstone, Yan Tu, Shenna Langenbach, David Baloyan, Andrew D Pattison, Peter Lock, Kara L Britt, Brian D Lehmann, Traude H Beilharz, Matthias Ernst, Robin L Anderson, Alastair G Stewart
CANCERS | MDPI | Published : 2021
Triple-negative breast cancer (TNBC) has a poor outcome compared to other breast cancer subtypes, and new therapies that target the molecular alterations driving tumor progression are needed. Annexin A1 is an abundant multi-functional Ca2+ binding and membrane-associated protein. Reported roles of Annexin A1 in breast cancer progression and metastasis are contradictory. Here, we sought to clarify the functions of Annexin A1 in the development and progression of TNBC. The association of Annexin A1 expression with patient prognosis in subtypes of TNBC was examined. Annexin A1 was stably knocked down in a panel of human and murine TNBC cell lines with high endogenous Annexin A1 expression that ..View full abstract
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Awarded by National Health and Medical Research Council (Australia)
This research was supported by National Health and Medical Research Council (Australia) project grants APP1023185 (to A.G.S. and C.N.J.), APP1128250 and APP1042848 (to T.H.B.), and APP1050384 and APP1020280 (to R.L.A.). We acknowledge the support of the Victorian Government Operational Infrastructure Support Program. We acknowledge The Collie Foundation for providing funds to purchase the Aperio slide scanner (Leica Microsystems).