Quantitative measures of bone shape, cartilage morphometry and joint alignment are associated with disease in an ACLT and MMx rat model of osteoarthritis
Bryce A Besler, Jemima E Schadow, Pholpat Durongbhan, Thomas H Steiner, Ryan J Choo, Martin A Zulliger, Markus Wilke, Kailash Atal, Colin Firminger, Aurelie Quintin, Bruno Koller, Ralph Muller, Dobrila Nesic, Kathryn S Stok
BONE | ELSEVIER SCIENCE INC | Published : 2021
Multi-scale, subject-specific quantitative methods to characterize and monitor osteoarthritis in animal models and therapeutic treatments could help reveal causal relationships in disease development and distinguish treatment strategies. In this work, we demonstrate a reproducible and sensitive quantitative image analysis to characterize bone, cartilage and joint measures describing a rat model of post-traumatic osteoarthritis. Eleven 3-month-old male Wistar rats underwent medial anterior cruciate ligament (ACL) transection and medial meniscectomy on the right knee to destabilise the right tibiofemoral joint. They were sacrificed 6 weeks post-surgery and a silicon-based micro-bead contrast a..View full abstract
Awarded by Swiss Commission for Technology and Innovation CTI
This study was supported by the Swiss Commission for Technology and Innovation CTI (Grant No. 9853.1) .