Effect of Testosterone Treatment on Bone Microarchitecture and Bone Mineral Density in Men: A 2-Year RCT
Mark Ng Tang Fui, Rudolf Hoermann, Karen Bracken, David J Handelsman, Warrick J Inder, Bronwyn GA Stuckey, Bu B Yeap, Ali Ghasem-Zadeh, Kristy P Robledo, David Jesudason, Jeffrey D Zajac, Gary A Wittert, Mathis Grossmann
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | ENDOCRINE SOC | Published : 2021
CONTEXT: Testosterone treatment increases bone mineral density (BMD) in hypogonadal men. Effects on bone microarchitecture, a determinant of fracture risk, are unknown. OBJECTIVE: We aimed to determine the effect of testosterone treatment on bone microarchitecture using high resolution-peripheral quantitative computed tomography (HR-pQCT). METHODS: Men ≥ 50 years of age were recruited from 6 Australian centers and were randomized to receive injectable testosterone undecanoate or placebo over 2 years on the background of a community-based lifestyle program. The primary endpoint was cortical volumetric BMD (vBMD) at the distal tibia, measured using HR-pQCT in 177 men (1 center). Secondary endp..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
There was no funding for this T4Bone substudy. The T4DM study was supported by grants from the National Health and Medical Research Council (NHMRC) Project Grant #1030123, Bayer, Lilly, and the University of Adelaide with in-kind support from Weight Watchers and Sonic Healthcare.