Causal Effects of Lifetime Smoking on Breast and Colorectal Cancer Risk: Mendelian Randomization Study.
Niki Dimou, James Yarmolinsky, Emmanouil Bouras, Konstantinos K Tsilidis, Richard M Martin, Sarah J Lewis, Inger T Gram, Marije F Bakker, Hermann Brenner, Jane C Figueiredo, Renée T Fortner, Stephen B Gruber, Bethany van Guelpen, Li Hsu, Rudolf Kaaks, Sun-Seog Kweon, Yi Lin, Noralane M Lindor, Polly A Newcomb, Maria-Jose Sánchez Show all
Cancer Epidemiol Biomarkers Prev | Published : 2021
BACKGROUND: Observational evidence has shown that smoking is a risk factor for breast and colorectal cancer. We used Mendelian randomization (MR) to examine causal associations between smoking and risks of breast and colorectal cancer. METHODS: Genome-Wide Association Study summary data were used to identify genetic variants associated with lifetime amount of smoking (n = 126 variants) and ever having smoked regularly (n = 112 variants). Using two-sample MR, we examined these variants in relation to incident breast (122,977 cases/105,974 controls) and colorectal cancer (52,775 cases/45,940 controls). RESULTS: In inverse-variance weighted models, a genetic predisposition to higher lifetime am..View full abstract
Awarded by Cancer Research UK