Journal article

Receptors in host pathogen interactions between human cytomegalovirus and the placenta during congenital infection

Krishneel Singh, Stuart T Hamilton, Antonia W Shand, Natalie J Hannan, William D Rawlinson

REVIEWS IN MEDICAL VIROLOGY | WILEY | Published : 2021

Abstract

Cellular receptors in human cytomegalovirus (HCMV) mother to child transmission play an important role in congenital infection. Placental trophoblast cells are a significant cell type in placental development, placental functional processes, and in HCMV transmission. Different cells within the placental floating and chorionic villi present alternate receptors for HCMV cell entry. Syncytiotrophoblasts present neonatal Fc receptors that bind and transport circulating maternal immunoglobulin G across the placental interface which can also be bound to HCMV virions, facilitating viral entry into the placenta and foetal circulation. Cytotrophoblast express HCMV receptors including integrin-α1β1, i..

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Grants

Awarded by National Health and Medical Research Council


Awarded by Thrasher Research Fund


Funding Acknowledgements

National Health and Medical Research Council, Grant/Award Number: APP1127717-Hamilton; Thrasher Research Fund, Grant/Award Number: RG181876-Hamilton