Small Non-coding RNAs Are Dysregulated in Huntington's Disease Transgenic Mice Independently of the Therapeutic Effects of an Environmental Intervention
Celine Dubois, Geraldine Kong, Harvey Tran, Shanshan Li, Terence Y Pang, Anthony J Hannan, Thibault Renoir
MOLECULAR NEUROBIOLOGY | SPRINGER | Published : 2021
Huntington's disease (HD) is a neurodegenerative disorder caused by a trinucleotide repeat expansion in the huntingtin gene. Transcriptomic dysregulations are well-documented in HD and alterations in small non-coding RNAs (sncRNAs), particularly microRNAs (miRNAs), could underpin that phenomenon. Additionally, environmental enrichment (EE), which is used to model a stimulating lifestyle in pre-clinical research, has been shown to ameliorate HD-related symptoms. However, the mechanisms mediating the therapeutic effects of EE remain largely unknown. This study assessed the effect of EE on sncRNA expression in the striatum of female R6/1 transgenic HD mice at 12 weeks (prior to over motor defic..View full abstract
This work was supported by a National Health and Medical Research (NHMRC) Project Grant to TR and AJH. TR is a NHMRC Boosting Dementia Research Leadership Fellow. AJH is a NHMRC Principal Research Fellow. The Florey Institute of Neuroscience and Mental Health acknowledges the support from the Victorian Government's Operational Infrastructure Support Grant.