Journal article

Place Cells in Head-Fixed Mice Navigating a Floating Real-World Environment

Mary Ann Go, Jake Rogers, Giuseppe P Gava, Catherine E Davey, Seigfred Prado, Yu Liu, Simon R Schultz

FRONTIERS IN CELLULAR NEUROSCIENCE | FRONTIERS MEDIA SA | Published : 2021

Abstract

The hippocampal place cell system in rodents has provided a major paradigm for the scientific investigation of memory function and dysfunction. Place cells have been observed in area CA1 of the hippocampus of both freely moving animals, and of head-fixed animals navigating in virtual reality environments. However, spatial coding in virtual reality preparations has been observed to be impaired. Here we show that the use of a real-world environment system for head-fixed mice, consisting of an air-floating track with proximal cues, provides some advantages over virtual reality systems for the study of spatial memory. We imaged the hippocampus of head-fixed mice injected with the genetically enc..

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University of Melbourne Researchers

Grants

Awarded by BBSRC


Awarded by EPSRC CDT in Neurotechnology for Life and Health (EPSRC)


Awarded by Universities UK Rutherford Fund


Funding Acknowledgements

This work was supported by BBSRCaward BB/R022437/1, by the EPSRC CDT in Neurotechnology for Life and Health (EPSRC award EP/L016737/1), by the Universities UK Rutherford Fund (award RF-2018-27), and by Mrs Anne Uren and the Michael Uren Foundation.