Automated assessment of functional lung imaging with Ga-68-ventilation/perfusion PET/CT using iterative histogram analysis
Lachlan McIntosh, Price Jackson, Nicholas Hardcastle, Mathias Bressel, Tomas Kron, Jason W Callahan, Daniel Steinfort, Nicholas Bucknell, Michael S Hofman, Shankar Siva
EJNMMI PHYSICS | SPRINGER | Published : 2021
PURPOSE: Functional lung mapping from Ga68-ventilation/perfusion (V/Q) PET/CT, which has been shown to correlate with pulmonary function tests (PFTs), may be beneficial in a number of clinical applications where sparing regions of high lung function is of interest. Regions of clumping in the proximal airways in patients with airways disease can result in areas of focal intense activity and artefact in ventilation imaging. These artefacts may even shine through to subsequent perfusion images and create a challenge for quantitative analysis of PET imaging. We aimed to develop an automated algorithm that interprets the uptake histogram of PET images to calculate a peak uptake value more represe..View full abstract
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Awarded by National Health and Medical Research Council
Shankar Siva has received National Health and Medical Research Council scholarship funding APP1038399.