High-quality reference genome for Clonorchis sinensis

Neil D Young; Andreas J Stroehlein; Liina Kinkar; Tao Wang; Woon-Mok Sohn; Bill CH Chang; Parwinder Kaur; David Weisz; Olga Dudchenko; Erez Lieberman Aiden; Pasi K Korhonen; Robin B Gasser

Journal article

High-quality reference genome for Clonorchis sinensis

Neil D Young, Andreas J Stroehlein, Liina Kinkar, Tao Wang, Woon-Mok Sohn, Bill CH Chang, Parwinder Kaur, David Weisz, Olga Dudchenko, Erez Lieberman Aiden, Pasi K Korhonen, Robin B Gasser

GENOMICS | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2021

DOI: 10.1016/j.ygeno.2021.03.001

Abstract

The Chinese liver fluke, Clonorchis sinensis, causes the disease clonorchiasis, affecting ~35 million people in regions of China, Vietnam, Korea and the Russian Far East. Chronic clonorchiasis causes cholangitis and can induce a malignant cancer, called cholangiocarcinoma, in the biliary system. Control in endemic regions is challenging, and often relies largely on chemotherapy with one anthelmintic, called praziquantel. Routine treatment carries a significant risk of inducing resistance to this anthelmintic in the fluke, such that the discovery of new interventions is considered important. It is hoped that the use of molecular technologies will assist this endeavour by enabling the identifi..

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University of Melbourne Researchers

Bill Chang Author Veterinary Biosciences

Robin Gasser Author Veterinary Biosciences

Tao Wang Author Veterinary Biosciences

Pasi Korhonen Author Veterinary Biosciences

Neil Young Author Veterinary Biosciences

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Grants

Awarded by Australian Research Council (ARC)

Awarded by NSF Physics Frontiers Center Award

Awarded by Welch Foundation

Awarded by USDA Agriculture and Food Research Initiative Grant

Awarded by NIH Encyclopedia of DNA Elements Mapping Center Award

Funding Acknowledgements

This project was supported through grants LP180101334 (N.D.Y. and P.K.K.) and LP180101085 (R.B.G. and BCCH) from the Australian Research Council (ARC). P.K.K. held an Early Career Research Fellowship from the National Health and Medical Research Council (NHMRC) of Australia. The in situ Hi-C sequencing and analysis was supported by DNA Zoo (Baylor College of Medicine) and DNA Zoo -Australia (The University of Western Australia), with additional computational resources and support from the Pawsey Supercomputing Centre, and funding from the Australian Government and the Government of Western Australia. E.L.A. was supported by an NSF Physics Frontiers Center Award (PHY1427654), the Welch Foundation (Q-1866), a USDA Agriculture and Food Research Initiative Grant (2017-05741), and an NIH Encyclopedia of DNA Elements Mapping Center Award (UM1HG009375).