Journal article

Dipylidium caninum draft genome-a new resource for comparative genomic and genetic explorations of flatworms

Guo-Hua Liu, Pasi K Korhonen, Neil D Young, Jiang Lu, Tao Wang, Yi-Tian Fu, Anson V Koehler, Andreas Hofmann, Bill CH Chang, Shuai Wang, Nan Li, Chu-Yu Lin, Hui Zhang, Lingzi Xiangli, Lin Lin, Wei-Min Liu, Nan Li, Hua-Wei Li, Robin B Gasser, Xing-Quan Zhu

GENOMICS | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2021

Abstract

Here, we present a draft genome of the tapeworm Dipylidium caninum (family Dipylidiidae) and compare it with other cestode genomes. This draft genome of D. caninum is 110 Mb in size, has a repeat content of ~13.4% and is predicted to encode ~10,000 protein-coding genes. We inferred excretory/secretory molecules (representing the secretome), other key groups of proteins (including peptidases, kinases, phosphatases, GTPases, receptors, transporters and ion-channels) and predicted potential intervention targets for future evaluation. Using 144 shared single-copy orthologous sequences, we investigated the genetic relationships of cestodes for which nuclear genomes are available. This study provi..

View full abstract

Grants

Awarded by International Science & Technology Cooperation Program of China


Awarded by Training Program for Excellent Young Innovators of Changsha


Awarded by Planned Program of Hunan Province Science and Technology Innovation


Awarded by Agricultural Science and Technology Innovation Program (ASTIP) of China


Funding Acknowledgements

This project was funded by the International Science & Technology Cooperation Program of China (grant no. 2013DFA31840) , the Training Program for Excellent Young Innovators of Changsha (grant no. KH2002001) , the Planned Program of Hunan Province Science and Technology Innovation (grant no. 2018RS3085) and the Agricultural Science and Technology Innovation Program (ASTIP) of China (grant no. CAASASTIP2016LVRI03) . Support from the Australian Research Council (ARC) , the National Health and Medical Research Council of Australia (NHMRC) and The University of Melbourne (RBG) is gratefully acknowledged. NDY and PKK held NHMRC Career Development and Early Career Research Fellowships, respectively.