Journal article

Original Research Ductal variant prostate carcinoma is associated with a significantly shorter metastasis-free survival

Ken Chow, Justin Bedo, Andrew Ryan, Dinesh Agarwal, Damien Bolton, Yee Chan, Philip Dundee, Mark Frydenberg, Marc A Furrer, Jeremy Goad, Dennis Gyomber, Uri Hanegbi, Laurence Harewood, Dennis King, Alastair D Lamb, Nathan Lawrentschuk, Peter Liodakis, Daniel Moon, Declan G Murphy, Justin S Peters Show all

EUROPEAN JOURNAL OF CANCER | ELSEVIER SCI LTD | Published : 2021

Abstract

BACKGROUND: Ductal adenocarcinoma is an uncommon prostate cancer variant. Previous studies suggest that ductal variant histology may be associated with worse clinical outcomes, but these are difficult to interpret. To address this, we performed an international, multi-institutional study to describe the characteristics of ductal adenocarcinoma, particularly focussing on the effect of presence of ductal variant cancer on metastasis-free survival. METHODS: Patients with ductal variant histology from two institutional databases who underwent radical prostatectomies were identified and compared with an independent acinar adenocarcinoma cohort. After propensity score matching, the effect of the p..

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Grants

Awarded by Cancer Research UK


Funding Acknowledgements

K.C. is supported by the Foundations for Surgery Research Scholarship from the Royal Australasian College of Surgeons, Postgraduate Medical Research Scholarship from the Prostate Cancer Research Fund and the Research Training Program Scholarship from the Australian Commonwealth Government. J.B. was supported by the Stafford Fox Medical Research Foundation. A.D.L. is funded by Cancer Research UK through a Clinician Scientist Fellowship (C57899/A25812). N.M.C. is supported by a Movember e Distinguished Gentleman's Ride Clinician Scientist Award through Prostate Cancer Foundation of Australia's Research Program.