Journal article

Cancer and Tumour Suppressor p53 Encounters at the Juncture of Sex Disparity

Sue Haupt, Ygal Haupt

Frontiers in Genetics | FRONTIERS MEDIA SA | Published : 2021

Abstract

There are many differences in cancer manifestation between men and women. New understanding of the origin of these point to fundamental distinctions in the genetic code and its demise. Tumour suppressor protein p53 is the chief operating officer of cancer defence and critically acts to safeguard against sustained DNA damaged. P53 cannot be ignored in cancer sex disparity. In this review we discuss the greater prevalence and associated death rates for non-reproductive cancers in males. The major tumour suppressor protein p53, encoded in the TP53 gene is our chosen context. It is fitting to ask why somatic TP53 mutation incidence is estimated to be disproportionately higher among males in the ..

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Grants

Funding Acknowledgements

The Haupt lab acknowledges funding from the following sources: Sister Institution Network Fund (SINF): MD Anderson-Peter Mac, and the Peter MacCallum Foundation.