Infant body mass index trajectories and asthma and lung function.
Gulshan Bano Ali, Dinh Son Bui, Caroline Jane Lodge, Nilakshi T Waidyatillake, Jennifer L Perret, Cong Sun, Eugene Haydn Walters, Michael John Abramson, Adrian J Lowe, Shyamali Chandrika Dharmage
J Allergy Clin Immunol | Published : 2021
BACKGROUND: The impact of early rapid increase in body mass index (BMI) on asthma risk and subsequent lung function remains contentious, with limited prospective studies during a critical window for lung growth. OBJECTIVE: Our aim was to investigate the associations between BMI trajectories in the first 2 years of life and adolescent asthma and lung function. METHODS: Anthropometric data on 620 infants from the Melbourne Atopy Cohort Study were collected up to 18 times in the first 24 months of the study. BMI trajectories were developed by using group-based trajectory modeling. Associations between these trajectories and spirometry, fractional exhaled nitric oxide level, and current asthma s..View full abstract