Journal article
Infant body mass index trajectories and asthma and lung function
GB Ali, DS Bui, CJ Lodge, NT Waidyatillake, JL Perret, C Sun, EH Walters, MJ Abramson, AJ Lowe, SC Dharmage
Journal of Allergy and Clinical Immunology | Published : 2021
Abstract
Background: The impact of early rapid increase in body mass index (BMI) on asthma risk and subsequent lung function remains contentious, with limited prospective studies during a critical window for lung growth. Objective: Our aim was to investigate the associations between BMI trajectories in the first 2 years of life and adolescent asthma and lung function. Methods: Anthropometric data on 620 infants from the Melbourne Atopy Cohort Study were collected up to 18 times in the first 24 months of the study. BMI trajectories were developed by using group-based trajectory modeling. Associations between these trajectories and spirometry, fractional exhaled nitric oxide level, and current asthma s..
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Funding Acknowledgements
The initial 6 years of funding for the Melbourne Atopy Cohort Study (MACS) was granted by Nestec, a branch of Nestle Australia. The Asthma Foundation of Victoria provided funds for the 12-year follow-up. The National Health and Medical Council of Australia funded the 18-year follow-up. The current follow-up of the MACS study has been funded by the National Health and Medical Council of Australia. None of the funding bodies supporting the establishment and ongoing follow-ups of theMACS had any role in the study design, collection, analysis, interpretation of the data, or writing of this article. The study design, results, conclusion, and implications reported in this article are those of the authors involved in the study.