Journal article
Plasma b vitamers: Population epidemiology and parent-child concordance in children and adults
S Andraos, B Jones, C Wall, E Thorstensen, M Kussmann, DC Smith, K Lange, S Clifford, R Saffery, D Burgner, M Wake, J O’Sullivan
Nutrients | Published : 2021
DOI: 10.3390/nu13030821
Abstract
Scope: B vitamers are co-enzymes involved in key physiological processes including energy production, one-carbon, and macronutrient metabolism. Studies profiling B vitamers simultaneously in parent–child dyads are scarce. Profiling B vitamers in parent–child dyads enables an insightful determination of gene–environment contributions to their circulating concentrations. We aimed to characterise: (a) parent–child dyad concordance, (b) generation (children versus adults), (c) age (within the adult subgroup (age range 28–71 years)) and (d) sex differences in plasma B vitamer concentrations in the CheckPoint study of Australian children. Methods and Results: 1166 children (11 ± 0.5 years, 51% fem..
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Awarded by Murdoch Children's Research Institute
Funding Acknowledgements
This study was funded by a MBIE Catalyst grant (The New Zealand-Australia Life Course Collaboration on Genes, Environment, Nutrition and Obesity (GENO); UOAX1611; to JOS & RS). The CheckPoint study was supported by the National Health and Medical Research Council (NHMRC) of Australia (Project Grants 1041352, 1109355), The Royal Children's Hospital Foundation (2014241), the Murdoch Children's Research Institute, The University of Melbourne, the National Heart Foundation of Australia (100660), Financial Markets Foundation for Children (2014-055, 2016-310) and the Victorian Deaf Education Institute. Research at the Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Support Program. The funding bodies did not play any role in the study. SA is the recipient of a New Zealand International Doctoral Research Scholarship 2017. The following authors were supported by NHMRC Research Fellowships: MW (1046518, 1160906) and DPB (1064629) as well as an Investigator Grant to DPB (GTN1175744). The following author was supported by the National Heart Foundation of Australia: Honorary Future Leader Fellowship to DPB (100369). MW was supported by Cure Kids New Zealand.