Journal article

Clinical utility of plasma EGFR mutation detection with quantitative PCR in advanced lung cancer: A meta-analysis

Peey-Sei Kok, Kirsty Lee, Sally Lord, James Chih-Hsin Yang, Rafael Rosell, Koichi Goto, Thomas John, Yi-Long Wu, Tony SK Mok, Chee Khoon Lee

LUNG CANCER | ELSEVIER IRELAND LTD | Published : 2021

Abstract

OBJECTIVES: To assess the clinical utility of quantitative PCR (qPCR) assays, a routinely used test for detection of epidermal growth factor receptor (EGFR) mutation in circulating tumour DNA (ctDNA) in treatment-naive advanced lung cancer patients. MATERIALS AND METHODS: We performed a meta-analysis of randomized controlled trials (RCTs) with individual patient data. Eligible RCTs compared EGFR-tyrosine kinase inhibitor (EGFR-TKI) and chemotherapy in first line setting for advanced lung cancer, and included tumour EGFR+ (tEGFR+) with paired ctDNA results using real-time (quantitative) PCR. We assessed the proportion of tEGFR + detected by ctDNA, and compared the effectiveness of EGFR-TKI ve..

View full abstract