The ability to form primary tumor xenografts is predictive of increased risk of disease recurrence in early-stage non-small cell lung cancer.
Thomas John, Derek Kohler, Melania Pintilie, Naoki Yanagawa, Nhu-An Pham, Ming Li, Devang Panchal, Frances Hui, Fannong Meng, Frances A Shepherd, Ming-Sound Tsao
Clinical Cancer Research | Published : 2011
PURPOSE: Primary tumor xenografts (PTXG) established directly from patients' primary tumors in immunosuppressed animals might represent the spectrum of histologic complexity of lung cancers better than xenografts derived from established cell lines. These models are important in the study of aberrant biological pathways in cancers and as preclinical models for testing new therapeutic agents. However, not all primary tumors engraft when implanted into immunosuppressed mice. We have investigated factors that may influence the ability of primary non-small cell lung cancer (NSCLC) to form xenografts and their association with clinical outcome. EXPERIMENTAL DESIGN: Tumor fragments from patients u..View full abstract