Conference Proceedings
Celtil score and long-term survival outcome in early stage HER2-positive (HER2 ) breast cancer treated with anti-HER2-based chemotherapy: A correlative analysis of neoALTTO trial
Nuria Chic, Stephen Luen, Paolo Nuciforo, Roberto Salgado, Debora Fumagalli, Florentine Hilbers, Yingbo Wang, Evandro de Azambuja, Itsvan Lang, Serena Di Cosimo, Cristina Saura, Jens Huober, Aleix Prat, Sherene Loi
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2021
Abstract
Abstract Background: Biomarkers to help escalate or de-escalate systemic therapies are urgently needed in early-stage HER2+ breast cancer patients. The combination of high stromal tumor infiltrating lymphocytes (TILs) and low tumor cellularity at 2 weeks of anti-HER2 therapy (CelTIL score) has been associated with high rates of pathologic complete response (pCR) after completion of neoadjuvant therapy. However, the value of CelTIL as a prognostic biomarker is unknown. Here, we present an independent validation of CelTIL in the NeoALTTO phase III trial. Methods: NeoALTTO randomized 455 patients (pts) with HER2+ early breast cancer to receive lapatinib (arm A), trastuzumab (Arm ..
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