Conference Proceedings
BluePrint performance in predicting pertuzumab benefit in genomically HER2-positive patients: A biomarker analysis of the APHINITY trial
Ian Krop, Lorenza Mittempergher, Joseph Paulson, Fabrice Andre, Herve Bonnefoi, Sherene Loi, Sibylle Loibl, Richard D Gelber, Carmela Caballero, Debora Fumagalli, Christa Dreezen, Rene Bernards, Laura van't Veer, Martine Piccart
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2021
Abstract
Abstract BACKGROUND:APHINITY is a phase III study (NCT01358877) which included 4805 patients (pts) with histologically centrally confirmed HER2+ early breast cancer (EBC) randomized to standard adjuvant chemotherapy (C) plus trastuzumab (T), plus either pertuzumab (P) or placebo1 for 1 year. With median follow up of 45 months, the primary analysis showed significant invasive disease-free survival (iDFS) benefit at 3 years with a hazard ratio (HR) of 0.81 (95% CI: 0.66-1.00; P = 0.045) for the addition of P to C/T1. BluePrint (BP) is an 80-gene molecular subtyping test that classifies EBC into functional basal, luminal and HER2 BP-subtypes3 according to gene expression. Previou..
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