Abstract P4-14-02: Analysis of DRFI and OS of HR-positive, HER2-negative breast cancer patients treated on the BIG1-98 study, classified according to a novel, integrated, clinical-pathologic and genomic classification method

Abstract

Abstract Background and Objectives HRpos, HER2neg early breast cancer is molecularly heterogeneous. Classifications that integrate genetic, genomic and clinical-pathologic data (nodal status, tumour size, tumour differentiation, Ki-67 status, PR expression) are lacking. In a previous study we have defined three different molecular groups of invasive ductal luminal breast cancer (IDLBC) using clinical prognostic variables, gene expression, copy number variation and mutation data from the METABRIC series [1, 2] and showed that IDLBC groups (IDLBC1, -2, -3) had distinct prognostic outcomes [3, 4]. The 3 groups differ by DNA damage load, predominant lesion type, cha..