The Effect of Early Sedation With Dexmedetomidine on Body Temperature in Critically Ill Patients*
Kim E Grayson, Michael Bailey, Mayurathan Balachandran, Piyusha P Banneheke, Alessandro Belletti, Rinaldo Bellomo, Thummaporn Naorungroj, Ary Serpa-Neto, Jason D Wright, Fumitaka Yanase, Paul J Young, Yahya Shehabi
CRITICAL CARE MEDICINE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2021
OBJECTIVES: Previous case series reported an association between dexmedetomidine use and hyperthermia. Temperature data have not been systematically reported in previous randomized controlled trials evaluating dexmedetomidine. A causal link between dexmedetomidine administration and elevated temperature has not been demonstrated. DESIGN: Post hoc analysis. SETTING: Four ICUs in Australia and New Zealand. PATIENTS: About 703 mechanically ventilated ICU patients. INTERVENTIONS: Early sedation with dexmedetomidine versus usual care. MEASUREMENTS AND MAIN RESULTS: The primary outcome was mean daily body temperature. Secondary outcomes included the proportions of patients with body temperatures g..View full abstract
Supported, in part, by The National Health and Medical Research Council of Australia and the Health Research Council of New Zealand funded in the Sedation Practice in Intensive Care Evaluation (SPICE III) study in the centers that provided data for this analysis. No funding was provided for this substudy, which was funded by institutional funds; SPICE III ClinicalTrials.gov number, NCT01728558.