Why trials lose participants: A multitrial investigation of participants' perspectives using the theoretical domains framework.
Rumana Newlands, Eilidh Duncan, Justin Presseau, Shaun Treweek, Louisa Lawrie, Peter Bower, Jim Elliott, Jill Francis, Graeme MacLennan, Margaret Ogden, Mary Wells, Miles D Witham, Bridget Young, Katie Gillies
J Clin Epidemiol | Elsevier BV | Published : 2021
OBJECTIVES: To use the Theoretical Domains Framework (TDF) to identify barriers and enablers to participant retention in trials requiring questionnaire return and/or attendance at follow-up clinics. STUDY DESIGN AND SETTING: We invited participants (n = 607) from five pragmatic effectiveness trials, who missed at least one follow-up time point (by not returning a questionnaire and/or not attending a clinic visit), to take part in semistructured telephone interviews. The TDF informed both data collection and analysis. To establish what barriers and enablers most likely influence the target behavior the domain relevance threshold was set at >75% of participants mentioning the domain. RESULTS: ..View full abstract