Journal article
Post-vaccination healthcare attendance rate as a proxy measure for syndromic surveillance of adverse events following immunisation
YM Mesfin, AC Cheng, J Enticott, J Lawrie, J Buttery
Australian and New Zealand Journal of Public Health | Published : 2021
Abstract
Objective: This study explored whether all-cause healthcare attendance rate post-vaccination could detect the two historical influenza safety episodes occurring in 2010 and 2015 using a large de-identified general practitioner (GP) consultations dataset. Methods: A retrospective observational cohort study was conducted using GP consultation data routinely collected from 2008 to 2017 in Victoria, Australia. Post-vaccination GP consultation rates were monitored, over a 22-week surveillance period each year that aligned with each year's influenza vaccination season, using the Observed minus Expected (O-E) and the Log-Likelihood Ratio (LLR) CUSUM charts. Days 1–7 post-vaccination were considered..
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Funding Acknowledgements
This research was supported by an Australian Government Research Training Program (RTP) Scholarship. The authors would like to thank Outcome Health for providing data. Funding: This research did not receive a specific grant from funding agencies in the public, commercial or not-for-profit sectors. Ethical approval: Approval for this project was obtained from the Monash Health Human Research Ethics Committee and data access approval was obtained from the Outcome Health POLAR research council