Bugs and Brains, the Gut and Mental Health Study: a mixed-methods study investigating microbiota composition and function in anxiety, depression and irritable bowel syndrome
Carra A Simpson, Orli S Schwartz, Djamila Eliby, Catherine A Butler, Katherine Huang, Neil O'Brien-Simpson, Bridget L Callaghan, Stuart G Dashper, Paul R Gooley, Sarah Whittle, Nick Haslam, Julian G Simmons
BMJ Open | BMJ PUBLISHING GROUP | Published : 2021
INTRODUCTION: Research has highlighted relationships between the micro-organisms that inhabit our gastrointestinal tract (oral and gut microbiota) with host mood and gastrointestinal functioning. Mental health disorders and functional gastrointestinal disorders co-occur at high rates, although the mechanisms underlying these associations remain unclear. The Bugs and Brains Study aims to investigate complex relationships between anxiety/depression and irritable bowel syndrome (IBS) in two ways. First, its primary component will compare the gut and oral microbiota in females with anxiety/depression and/or IBS relative to controls, and investigate underlying physiological, endocrine and immune ..View full abstract
Awarded by National Health and Medical Research Council
This research is funded by the Melbourne School of Psychological Sciences. Carra Simpson is supported by the Australian Government Research Training Programme. This work was funded by the National Health and Medical Research Council (Career Development Fellowship to SW, ID 1125504).