Journal article
Independent associations of lymphopenia and neutropenia in patients with systemic lupus erythematosus: A longitudinal, multinational study
R Kandane-Rathnayake, W Louthrenoo, V Golder, SF Luo, YJJ Wu, A Lateef, J Cho, Z Li, Y An, L Hamijoyo, S Navarra, L Zamora, Y Katsumata, M Harigai, S Sockalingam, M Chan, YH Chen, S O'neill, F Goldblatt, Y Hao Show all
Rheumatology United Kingdom | OXFORD UNIV PRESS | Published : 2021
Abstract
Objective. The prevalence and associations of leucopenia in SLE remain incompletely understood. We evaluated associations of disease activity and medication use with leucopenia (lymphopenia and neutropenia) in a multinational, prospectively followed SLE cohort. Methods. Data from the Asia Pacific Lupus Collaboration cohort, in which disease activity and medications were prospectively captured from 2013 to 2018, were used. Predictors of lymphopenia (lymphocyte count <0.8×109/l) and neutropenia (neutrophil count <1.5×109/l) were examined using multiple failure, time-dependent survival analyses. Results. Data from 2330 patients and 18 287 visits were analysed. One thousand and eighteen patients..
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Funding Acknowledgements
The APLC received funding from AstraZeneca, Bristol-Myers Squibb, Eli Lilly, EMD Serono, GlaxoSmithKline, Janssen, and UCB Biopharma in support of its research activities. The funders had no role in study design, data analysis, results interpretation or writing of this manuscript.