Journal article

Trajectories of change in depression symptoms and suicidal ideation over the course of evidence-based treatment for depression: Secondary analysis of a randomised controlled trial of cognitive behavioural therapy plus fluoxetine in young people

Katrina Witt, Trine Madsen, Michael Berk, Olivia Dean, Andrew Chanen, Patrick D McGorry, Sue Cotton, Christopher G Davey, Sarah Hetrick

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY | SAGE PUBLICATIONS LTD | Published : 2021

Abstract

OBJECTIVES: Effective treatment of depression is a key target for suicide prevention strategies. However, only around one-third of young people with suicide risk respond to evidence-based treatments. Understanding the trajectory of suicidal ideation, as a marker of suicide risk, over the course of evidence-based treatment for depression might provide insight into more targeted and effective treatments. METHODS: This is a secondary analysis of data from the multicentre Youth Depression Alleviation-Combined Treatment trial. A total of 153 young people aged 15-25 years diagnosed with major depressive disorder were randomly assigned in this double-blind, placebo-controlled trial to either cognit..

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Grants

Awarded by NHMRC


Funding Acknowledgements

The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: The YODA-C trial received funding from the Australian National Health and Medical Research Council (NHMRC). Individual authors also report the following funding: M.B. is supported by two NHMRC Senior Principal Research Fellowships (1059660 and 1156072). O.D. is a R.D. Wright Biomedical NHMRC Career Development Fellow (1145634). S.C. is supported by a NHMRC Senior Research Fellowship (APP1136344). S.H. is funded by an Auckland Medical Research Foundation Douglas Goodfellow Repatriation Fellowship and is the CureKids Research Fellow. K.W. is funded by an Emerging Leadership 1 Fellowship awarded by the NHMRC.