Journal article

THE EFFECT OF SMOKING ON PITUITARY-ADRENAL AXIS

M SELLINI, S BACCARINI, E DIMITRIADIS, MP SARTORI, C LETIZIA

MEDICINA-RIVISTA DELLA ENCICLOPEDIA MEDICA ITALIANA | MEDICINA-RIV EMI | Published : 1989

Abstract

Plasma concentrations of adrenocorticotrophin (ACTH) and cortisol were measured during insulin-induced hypoglycemia and lysin-8-vasopressin (LVP) test in 60 healthy subjects, non-smokers and habitually smokers of 10 or more cigarettes/24 hours. A marked and statistically significant rise of both hormones was found in non-smoker subjects, whereas smokers showed poor and not significant modifications. These results suggest that continuous chronic inhalation of nicotine may act as a powerful stimulus on the hypothalamo-hypophyseal structures that control the hypothalamic CRF and/or ACTH production and release. Central nervous mechanisms of hormonal regulation may become less sensitive and effic..

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