Platelets in Multiple Sclerosis: Early and Central Mediators of Inflammation and Neurodegeneration and Attractive Targets for Molecular Imaging and Site-Directed Therapy
Jacqueline M Orian, Claretta S D'Souza, Pece Kocovski, Guy Krippner, Matthew W Hale, Xiaowei Wang, Karlheinz Peter
FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2021
Platelets are clearly central to thrombosis and hemostasis. In addition, more recently, evidence has emerged for non-hemostatic roles of platelets including inflammatory and immune reactions/responses. Platelets express immunologically relevant ligands and receptors, demonstrate adhesive interactions with endothelial cells, monocytes and neutrophils, and toll-like receptor (TLR) mediated responses. These properties make platelets central to innate and adaptive immunity and potential candidate key mediators of autoimmune disorders. Multiple sclerosis (MS) is the most common chronic autoimmune central nervous system (CNS) disease. An association between platelets and MS was first indicated by ..View full abstract
Awarded by La Trobe University Research Focus Area scheme
CD'S was supported by a La Trobe University Post-graduate Research scholarship and PK by an Australian Research Training scholarship. JO was funded by the La Trobe University Research Focus Area scheme (grant number: 2000004433) and the La Trobe Alumni, XW by a Future Leader Fellowship of the National Heart Foundation of Australia (NHF), and KP by a Leadership Level 3 Fellowship of the Australian National Health and Medical Research Council (NHMRC). The authors would like to thank the La Trobe Animal Research and Training Facility and La Trobe Institute for Molecular Science Bioimaging Platform.