Journal article
Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa
J Freff, K Schwarte, L Bröker, J Bühlmeier, I Kraft, D Öztürk, A Hinney, V Arolt, U Dannlowski, G Romer, BT Baune, J Hebebrand, M Föcker, J Alferink
Scientific Reports | NATURE PORTFOLIO | Published : 2021
Abstract
Anorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n = 24) and after 6 weeks (T1, n = 20) of treatment. Using multi-parameter flow cytometry, we found increased percentages of antigen-experienced B cells and plasmablasts in patients with AN compared to healthy controls (n =..
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Awarded by Deutsche Forschungsgemeinschaft
Funding Acknowledgements
Open Access funding enabled and organized by Projekt DEAL. AH has beenfunded by the German Research Foundation (DFG; HI865/2-1), the Landesprogramm fur Geschlechtergerechte Hochschulen-Programmstrang Forderung von Denominationen in der Genderforschung and the Medical Faculty of the University of DuisburgEssen. The work of JA has been funded by the DFG EXC 1003, Grant FF-2014-01 Cells in Motion-Cluster of Excellence, Munster, Germany, and by the DFG FOR2107 AL1145/5-2. The clinical characterization of patients and HC including body composition measurements were founded by intramural funds of the University Hospital Essen provided to the Department of Child and Adolescent Psychiatry.