Alterations in B cell subsets correlate with body composition parameters in female adolescents with anorexia nervosa
Jana Freff, Kathrin Schwarte, Lisa Broeker, Judith Buehlmeier, Isabelle Kraft, Dana Oeztuerk, Anke Hinney, Volker Arolt, Udo Dannlowski, Georg Romer, Bernhard T Baune, Johannes Hebebrand, Manuel Focker, Judith Alferink
Scientific Reports | NATURE RESEARCH | Published : 2021
Anorexia nervosa (AN) is a severe eating disorder and often associated with altered humoral immune responses. However, distinct B cell maturation stages in peripheral blood in adolescents with AN have not been characterized. Treatment effects and the relationship between clinical and B cell parameters are also not fully understood. Here we investigated the phenotype of circulating B cell subsets and the relationship with body composition in adolescents with AN before (T0, n = 24) and after 6 weeks (T1, n = 20) of treatment. Using multi-parameter flow cytometry, we found increased percentages of antigen-experienced B cells and plasmablasts in patients with AN compared to healthy controls (n =..View full abstract
Awarded by German Research Foundation (DFG)
Awarded by DFG
Open Access funding enabled and organized by Projekt DEAL. AH has beenfunded by the German Research Foundation (DFG; HI865/2-1), the Landesprogramm fur Geschlechtergerechte Hochschulen-Programmstrang Forderung von Denominationen in der Genderforschung and the Medical Faculty of the University of DuisburgEssen. The work of JA has been funded by the DFG EXC 1003, Grant FF-2014-01 Cells in Motion-Cluster of Excellence, Munster, Germany, and by the DFG FOR2107 AL1145/5-2. The clinical characterization of patients and HC including body composition measurements were founded by intramural funds of the University Hospital Essen provided to the Department of Child and Adolescent Psychiatry.