Journal article

Plasma Amyloid-Beta Levels in a Pre-Symptomatic Dutch-Type Hereditary Cerebral Amyloid Angiopathy Pedigree: A Cross-Sectional and Longitudinal Investigation

Pratishtha Chatterjee, Michelle Tegg, Steve Pedrini, Anne M Fagan, Chengjie Xiong, Abhay K Singh, Kevin Taddei, Samantha Gardener, Colin L Masters, Peter R Schofield, Gerhard Multhaup, Tammie LS Benzinger, John C Morris, Randall J Bateman, Steven M Greenberg, Mark A van Buchem, Erik Stoops, Hugo Vanderstichele, Charlotte E Teunissen, Graeme J Hankey Show all

International Journal of Molecular Sciences | MDPI | Published : 2021

Abstract

Plasma amyloid-beta (Aβ) has long been investigated as a blood biomarker candidate for Cerebral Amyloid Angiopathy (CAA), however previous findings have been inconsistent which could be attributed to the use of less sensitive assays. This study investigates plasma Aβ alterations between pre-symptomatic Dutch-type hereditary CAA (D-CAA) mutation-carriers (MC) and non-carriers (NC) using two Aβ measurement platforms. Seventeen pre-symptomatic members of a D-CAA pedigree were assembled and followed up 3-4 years later (NC = 8; MC = 9). Plasma Aβ1-40 and Aβ1-42 were cross-sectionally and longitudinally analysed at baseline (T1) and follow-up (T2) and were found to be lower in MCs compared to NCs,..

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