Journal article

Arginine glycosylation enhances methylglyoxal detoxification

Samir El Qaidi, Nichollas E Scott, Philip R Hardwidge

Scientific Reports | NATURE RESEARCH | Published : 2021

Abstract

Type III secretion system effector proteins have primarily been characterized for their interactions with host cell proteins and their ability to disrupt host signaling pathways. We are testing the hypothesis that some effectors are active within the bacterium, where they modulate bacterial signal transduction and physiology. We previously determined that the Citrobacter rodentium effector NleB possesses an intra-bacterial glycosyltransferase activity that increases glutathione synthetase activity to protect the bacterium from oxidative stress. Here we investigated the potential intra-bacterial activities of NleB orthologs in Salmonella enterica and found that SseK1 and SseK3 mediate resista..

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University of Melbourne Researchers

Grants

Awarded by National Institute of Allergy and Infectious Diseases (NIAID)


Awarded by National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health


Awarded by National Health and Medical Research Council of Australia (NHMRC)


Funding Acknowledgements

The project described was supported by Grant numbers AI127973 and AI153202 from the National Institute of Allergy and Infectious Diseases (NIAID) and by the National Institute of General Medical Sciences (NIGMS) of the National Institutes of Health under award number P20GM130448 (PRH). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the National Institutes of Health. This work was also supported by National Health and Medical Research Council of Australia (NHMRC) project Grants awarded to NES (APP1100164). We thank the Melbourne Mass Spectrometry and Proteomics Facility of The Bio21 Molecular Science and Biotechnology Institute at The University of Melbourne for the support of mass spectrometry analysis.