Cycles in epilepsy
Philippa J Karoly, Vikram R Rao, Nicholas M Gregg, Gregory A Worrell, Christophe Bernard, Mark J Cook, Maxime O Baud
NATURE REVIEWS NEUROLOGY | NATURE RESEARCH | Published : 2021
Epilepsy is among the most dynamic disorders in neurology. A canonical view holds that seizures, the characteristic sign of epilepsy, occur at random, but, for centuries, humans have looked for patterns of temporal organization in seizure occurrence. Observations that seizures are cyclical date back to antiquity, but recent technological advances have, for the first time, enabled cycles of seizure occurrence to be quantitatively characterized with direct brain recordings. Chronic recordings of brain activity in humans and in animals have yielded converging evidence for the existence of cycles of epileptic brain activity that operate over diverse timescales: daily (circadian), multi-day (mult..View full abstract
Awarded by Swiss National Science Foundation
Awarded by Velux Stiftung
The research of M.O.B. is supported by the Swiss National Science Foundation in the form of an Ambizione grant, number PZ00P3_ 179929/1, and by the Velux Stiftung, grant #1232. V.R.R. is supported by the Ernest Gallo Foundation Distinguished Professorship in Neurology at the University of California, San Francisco.