Journal article

Cycles in epilepsy

Philippa J Karoly, Vikram R Rao, Nicholas M Gregg, Gregory A Worrell, Christophe Bernard, Mark J Cook, Maxime O Baud



Epilepsy is among the most dynamic disorders in neurology. A canonical view holds that seizures, the characteristic sign of epilepsy, occur at random, but, for centuries, humans have looked for patterns of temporal organization in seizure occurrence. Observations that seizures are cyclical date back to antiquity, but recent technological advances have, for the first time, enabled cycles of seizure occurrence to be quantitatively characterized with direct brain recordings. Chronic recordings of brain activity in humans and in animals have yielded converging evidence for the existence of cycles of epileptic brain activity that operate over diverse timescales: daily (circadian), multi-day (mult..

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Awarded by Swiss National Science Foundation

Awarded by Velux Stiftung

Funding Acknowledgements

The research of M.O.B. is supported by the Swiss National Science Foundation in the form of an Ambizione grant, number PZ00P3_ 179929/1, and by the Velux Stiftung, grant #1232. V.R.R. is supported by the Ernest Gallo Foundation Distinguished Professorship in Neurology at the University of California, San Francisco.