Journal article
Communicating polygenic risk scores in the familial breast cancer clinic
K Das Gupta, G Gregory, B Meiser, R Kaur, M Scheepers-Joynt, S McInerny, S Taylor, K Barlow-Stewart, Y Antill, L Salmon, C Smyth, A McInerney-Leo, MA Young, PA James, T Yanes
Patient Education and Counseling | ELSEVIER IRELAND LTD | Published : 2021
Abstract
Objective: To describe the communication of polygenic risk scores (PRS) in the familial breast cancer setting. Methods: Consultations between genetic healthcare providers (GHP) and female patients who received their PRS for breast cancer risk were recorded (n = 65). GHPs included genetic counselors (n = 8) and medical practitioners (n = 5) (i.e. clinical geneticists and oncologists). A content analysis was conducted and logistic regression was used to assess differences in communication behaviors between genetic counselors (n = 8) and medical practitioners (n = 5). Results: Of the 65 patients, 31 (47.7 %) had a personal history of breast cancer, 18 of whom received an increased PRS (relative..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was supported by a grant from the Cancer Council of New South Wales (ID: 1079897). TY was supported by a National Health and Medical Research Council (NHMRC) and National Breast Cancer Foundation postgraduate scholarship (ID:1133049), and a Translational Cancer Research Institute PhD Top-up Scholarship. BM is supported by an NHMRC Senior Research Fellowship Level B (ID 1078523) and AML is supported by an NHMRC Early Career Fellowship (ID 1158111).