Communicating polygenic risk scores in the familial breast cancer clinic.

Kuheli Das Gupta; Gillian Gregory; Bettina Meiser; Rajneesh Kaur; Maatje Scheepers-Joynt; Simone McInerny; Shelby Taylor; Kristine Barlow-Stewart; Yoland Antill; Lucinda Salmon; Courtney Smyth; Aideen McInerney-Leo; Mary-Anne Young; Paul A James; Tatiane Yanes

Journal article

Communicating polygenic risk scores in the familial breast cancer clinic.

Kuheli Das Gupta, Gillian Gregory, Bettina Meiser, Rajneesh Kaur, Maatje Scheepers-Joynt, Simone McInerny, Shelby Taylor, Kristine Barlow-Stewart, Yoland Antill, Lucinda Salmon, Courtney Smyth, Aideen McInerney-Leo, Mary-Anne Young, Paul A James, Tatiane Yanes

Patient Educ Couns | Published : 2021

DOI: 10.1016/j.pec.2021.02.046

Abstract

OBJECTIVE: To describe the communication of polygenic risk scores (PRS) in the familial breast cancer setting. METHODS: Consultations between genetic healthcare providers (GHP) and female patients who received their PRS for breast cancer risk were recorded (n = 65). GHPs included genetic counselors (n = 8) and medical practitioners (n = 5) (i.e. clinical geneticists and oncologists). A content analysis was conducted and logistic regression was used to assess differences in communication behaviors between genetic counselors (n = 8) and medical practitioners (n = 5). RESULTS: Of the 65 patients, 31 (47.7 %) had a personal history of breast cancer, 18 of whom received an increased PRS (relative..

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