Journal article

Uptake of hysterectomy and bilateral salpingooophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report

Toni T Seppala, Mev Dominguez-Valentin, Emma J Crosbie, Christoph Engel, Stefan Aretz, Finlay Macrae, Ingrid Winship, Gabriel Capella, Huw Thomas, Eivind Hovig, Maartje Nielsen, Rolf H Sijmons, Lucio Bertario, Bernardo Bonanni, Maria G Tibiletti, Giulia M Cavestro, Miriam Mints, Nathan Gluck, Lior Katz, Karl Heinimann Show all



PURPOSE: This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. METHODS: The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. RESULTS: Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%..

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Awarded by "Pink ribbon" grant from Den Norske Kreftforening

Awarded by Norwegian Cancer Society

Awarded by All Manchester National Institute for Health Research (NIHR) Biomedical Research Centre

Awarded by National Cancer Institute of the National Institutes of Health

Awarded by Dutch Cancer Society (DCS)

Awarded by FEDER funds, a way to build Europe

Awarded by Government of Catalonia

Funding Acknowledgements

The study was supported by a "Pink ribbon" grant #194751 from Den Norske Kreftforening to EH. The authors would like to express our gratitude to Heikki Jarvinen, Beatrice Alcala-Repo, Teresa Ocana, Maria Pellise, Sabela Carballal, Liseth Rivero, Lorena Moreno, Gerhard Jung, Antoni Castells, Joaquin Cubiella, Laura Rivas, Luis Bujanda, Ines Gil, Jesus Banales, Catalina Garau, Rodrigo Jover, Maria Dolores Pico, Xavier Bessa, Cristina Alvarez, Montserrat Andreu, Carmen Poves, Pedro Perez Segura, Lucia Cid, Marta Carrillo, Enrique Quintero, Angeles Pizarro, Marta Garzon, Adolfo Suarez, Inmaculada Salces, Daniel Rodriguez-Alcalde, Judith Balmana, Adria Lopez, Nuria Duenas, Gemma Llort, Carmen Yague, Teresa Ramon i Cajal, David Fisas Masferrer, Alexandra Gisbert Beamud, Consol Lopez San Martin, Maite Herraiz, Pilar Perez, Cristina Carretero, Maite Betes, Marta Ponce, Elena Aguirre, Nora Alfaro, Carlos Sarroca, and Marianne Haeusler for their efforts over many years. The CCFR graciously thanks the generous contributions of their study participants and dedication of study staff.The authors would also like to thank Cancer Foundation Finland, Jane and Aatos Erkko Foundation, Emil Aaltonen Foundation, Finnish Medical Foundation, Sigrid Juselius Foundation, Instrumentarium Science Foundation, iCAN Flagship of the Academy of Finland, and the Norwegian Cancer Society, contract 194751-2017, for funding. DGE and EJC are supported by the All Manchester National Institute for Health Research (NIHR) Biomedical Research Centre (ISBRC-1215-20007) and JRS by Health and Care Research Wales through Wales Gene Park. The CCFR is supported in part by the National Cancer Institute of the National Institutes of Health under Award Number UM1CA167551. The German Consortium for Familial Intestinal Cancer has been supported by grants from the German Cancer Aid. Data collection from Wales, UK, was supported by the Wales Gene Park. This work was co-funded by the European Regional Development Fund (ERDF). MN and StB were supported by a grant from the Dutch Cancer Society (DCS), grant number UL 2017-8223. Gabriel Capella, Marta Pineda, and Joan Brunet were funded by the Spanish Ministry of Economy and Competitiveness and co-funded by FEDER funds, a way to build Europe (grant SAF201568016-R), CIBERONC, and the Government of Catalonia (grant 2017SGR1282). The authors thank CERCA Programme/Generalitat de Catalunya for institutional support. The work was also partially supported by the Italian Ministry of Health with Ricerca Corrente and 5X1000 funds.