Journal article

Control trial of porcine cysticercosis in Uganda using a combination of the TSOL18 vaccination and oxfendazole

Zachary Nsadha, Chris Rutebarika, Chrisostom Ayebazibwe, Bukenya Aloys, M Mwanja, E Jane Poole, Elizabeth Chesang, Angela Colston, Meritxell Donadeu, Marshall W Lightowlers

Infectious Diseases of Poverty | BMC | Published : 2021

Abstract

BACKGROUND: Neurocysticercosis caused by Taenia solium when the parasite lodges in the central nervous system, is an important cause of human seizures and mortality in sub-Saharan Africa. The parasite is prevalent in many regions of Uganda. Pigs are intermediate hosts for T. solium, and we evaluated a T. solium control program in pigs, involving vaccination of pigs with the TSOL18 vaccine and treatment with oxfendazole. METHODS: The study was conducted in two districts of Eastern Uganda involving the rural village communities of Bukedea (intervention area) and Kumi (control area) during 2016-2017. Seven hundred and thirty-four households were enrolled in the study. Pigs in the intervention a..

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University of Melbourne Researchers

Grants

Awarded by Bill & Melinda Gates Foundation


Awarded by UK Government


Awarded by Australian National Health and Medical Research Council


Funding Acknowledgements

This project funded in part by the Bill & Melinda Gates Foundation (OPP1009497; GALVmed) and the UK Government (Component Code 203188101; GALVmed). Funding is acknowledged from the Australian National Health and Medical Research Council Grant GTN1105448 (MWL). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the Bill & Melinda Gates Foundation nor the UK Government.