The effectiveness of the 13-valent pneumococcal conjugate vaccine against hypoxic pneumonia in children in Lao People's Democratic Republic: An observational hospital-based test-negative study
Rupert Weaver, Cattram D Nguyen, Jocelyn Chan, Keoudomphone Vilivong, Jana YR Lai, Ruth Lim, Catherine Satzke, Malisa Vongsakid, Paul N Newton, Kim Mulholland, Amy Gray, Audrey Dubot-Peres, David AB Dance, Fiona M Russell
LANCET REGIONAL HEALTH-WESTERN PACIFIC | ELSEVIER | Published : 2020
Background: Pneumococcal pneumonia is a leading cause of childhood mortality. Pneumococcal conjugate vaccines (PCVs) have been shown to reduce hypoxic pneumonia in children. However, there are no studies from Asia examining the effectiveness of PCVs on hypoxic pneumonia. We describe a novel approach to determine the effectiveness of the 13-valent PCV (PCV13) against hypoxia in children admitted with pneumonia in the Lao People's Democratic Republic. Methods: A prospective hospital-based, test-negative observational study of children aged up to 59 months admitted with pneumonia to a single tertiary hospital in Vientiane was undertaken over 54 months. Pneumonia was defined using the 2013 WHO d..View full abstract
Awarded by Bill & Melinda Gates Foundation
Awarded by NHMRC
The field work was supported by funding from the Bill & Melinda Gates Foundation (OPP1115490). We would also like to acknowledge the study and laboratory staffat: Asia-Pacifc Health Research Group, Murdoch Children's Reseach Institute, Melbourne, Australia; Centre for International Child Health, Dept. of Paediatrics, The University of Melbourne, Australia; Translational Microbiology Group, Murdoch Children's Research Institute, Australia; Expanded Programme of Immunization, Ministry of Health Laos; Lao-Oxford-Mahosot Hospital-Wellcome Trust-Research Unit, Vientiane, Laos; HRSV testing was funded by Institute of Research for Development (IRD) and Aix-Marseille University Centre for Tropical Medicine & Global Health, University of Oxford, Oxford, UK; London School of Hygiene and Tropical Medicine, London, UK. Fiona Russell received a NHMRC ECF, TRIP Fellowship and Investigator Grant. Paul Newton and David Dance are supported by the Wellcome Trust which also core funds LOMWRU. Catherine Satzke was supported by a NHMRC Career Development Fellowship (1087957) and a Veski Inspiring Women Fellowship. The Murdoch Children's Research Institute was supported by the Victorian Government's Operational Infrastructure Support Program. The funding sources did not have any involvement in the study design, the collection, analysis, and interpretation of data; or in the writing of the report; and the decision to submit the paper for publication.