CD4 and CD8 T Cells in Murine Virus Infections: Experiments with Lymphocytic Choriomeningitis and Influenza

Abstract

Much of the analysis of T cell function in virus-specific cellmediated immunity [CMI] in the mouse has concentrated on the CD8+, class I major histocompatibility complex [MHC] restricted effector population. Part of the reason for this is that the early cytotoxic T lymphocyte [CTL] assays were done only with class I MHC+, virus-infected taget cells [Zinkernagel and Doherty, 1979]. Also, it was apparent from the initial adoptive transfer experiments with the lymphocytic choriomeningitis [LCM] model that both the induction of inflammation in the central nervous system [CNS] and the promotion of virus clearance from extraneural sites were properties of the class I MHC-restricted T cell subset. ..