Postpartum circulating microRNA enhances prediction of future type 2 diabetes in women with previous gestational diabetes
Mugdha V Joglekar, Wilson KM Wong, Fahmida K Ema, Harry M Georgiou, Alexis Shub, Anandwardhan A Hardikar, Martha Lappas
Diabetologia | SPRINGER | Published : 2021
AIMS/HYPOTHESIS: Type 2 diabetes mellitus is a major cause of morbidity and death worldwide. Women with gestational diabetes mellitus (GDM) have greater than a sevenfold higher risk of developing type 2 diabetes in later life. Accurate methods for postpartum type 2 diabetes risk stratification are lacking. Circulating microRNAs (miRNAs) are well recognised as biomarkers/mediators of metabolic disease. We aimed to determine whether postpartum circulating miRNAs can predict the development of type 2 diabetes in women with previous GDM. METHODS: In an observational study, plasma samples were collected at 12 weeks postpartum from 103 women following GDM pregnancy. Utilising a discovery approach,..View full abstract
The work described in this manuscript was funded by the Norman Beischer Medical Research Foundation (to ML, HMG) and Diabetes Australia (to ML). MVJ, WKMWandAAH aremainly supported through fellowships/grants from the JDRF Australia, Australian Diabetes Society or JDRF International, USA. AAH is also supported through Visiting Professorships (2017-18 and 2019-22) from the Danish Diabetes Academy (funded through the Novo Nordisk Foundation).